Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole

BACKGROUND: Chagas Disease is the leading cause of heart failure in Latin America. Current drug therapy is limited by issues of both efficacy and severe side effects. Trypansoma cruzi, the protozoan agent of Chagas Disease, is closely related to two other major global pathogens, Leishmania spp., res...

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Main Authors: Chen, Chiung-Kuang, Leung, Siegfried S. F., Guilbert, Christophe, Jacobson, Matthew P., McKerrow, James H., Podust, Larissa M.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2010
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850312/
https://ncbi.nlm.nih.gov/pubmed/20386598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0000651
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