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Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole

BACKGROUND: Chagas Disease is the leading cause of heart failure in Latin America. Current drug therapy is limited by issues of both efficacy and severe side effects. Trypansoma cruzi, the protozoan agent of Chagas Disease, is closely related to two other major global pathogens, Leishmania spp., res...

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Библиографические подробности
Главные авторы: Chen, Chiung-Kuang, Leung, Siegfried S. F., Guilbert, Christophe, Jacobson, Matthew P., McKerrow, James H., Podust, Larissa M.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850312/
https://ncbi.nlm.nih.gov/pubmed/20386598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0000651
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