R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi

[Image: see text] Sterol 14α-demethylase (CYP51) is an important therapeutic target for fungal and parasitic infections due to its key role in the biosynthesis of ergosterol, an essential component of the cell membranes of these pathogenic organisms. We report the development of potent and selective...

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Bibliografiske detaljer
Main Authors: Choi, Jun Yong, Calvet, Claudia M., Vieira, Debora F., Gunatilleke, Shamila S., Cameron, Michael D., McKerrow, James H., Podust, Larissa M., Roush, William R.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027616/
https://ncbi.nlm.nih.gov/pubmed/24900854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500010m
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