Loading...
R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi
[Image: see text] Sterol 14α-demethylase (CYP51) is an important therapeutic target for fungal and parasitic infections due to its key role in the biosynthesis of ergosterol, an essential component of the cell membranes of these pathogenic organisms. We report the development of potent and selective...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Chemical
Society
2014
|
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027616/ https://ncbi.nlm.nih.gov/pubmed/24900854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500010m |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|