4-Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency

[Image: see text] CYP51 is a P450 enzyme involved in the biosynthesis of the sterol components of eukaryotic cell membranes. CYP51 inhibitors have been developed to treat infections caused by fungi, and more recently the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. To...

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Hlavní autoři: Calvet, Claudia M., Vieira, Debora F., Choi, Jun Yong, Kellar, Danielle, Cameron, Michael D., Siqueira-Neto, Jair Lage, Gut, Jiri, Johnston, Jonathan B., Lin, Li, Khan, Susan, McKerrow, James H., Roush, William R., Podust, Larissa M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148169/
https://ncbi.nlm.nih.gov/pubmed/25101801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500448u
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