Binding Mode and Potency of N-Indolyloxopyridinyl-4-aminopropanyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51

[Image: see text] Chagas disease is a chronic infection in humans caused by Trypanosoma cruzi and manifested in progressive cardiomyopathy and/or gastrointestinal dysfunction. Limited therapeutic options to prevent and treat Chagas disease put 8 million people infected with T. cruzi worldwide at ris...

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Publicado en:J Med Chem
Autores principales: Vieira, Debora F., Choi, Jun Yong, Calvet, Claudia M., Siqueira-Neto, Jair Lage, Johnston, Jonathan B., Kellar, Danielle, Gut, Jiri, Cameron, Michael D., McKerrow, James H., Roush, William R., Podust, Larissa M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2014
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266343/
https://ncbi.nlm.nih.gov/pubmed/25393646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501568b
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