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Methyl Effects on Protein–Ligand Binding
The effects of addition of a methyl group to a lead compound on biological activity are examined. A literature analysis of >2000 cases reveals that an activity boost of a factor of ten or more is found with an 8% frequency, and a 100-fold boost is a 1 in 200 event. Four cases in the latter catego...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3353327/ https://ncbi.nlm.nih.gov/pubmed/22500930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3003697 |
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