A Nonazole CYP51 Inhibitor Cures Chagas’ Disease in a Mouse Model of Acute Infection

Chagas’ disease, the leading cause of heart failure in Latin America, is caused by the kinetoplastid protozoan Trypanosoma cruzi. The sterols of T. cruzi resemble those of fungi, both in composition and in biosynthesis. Azole inhibitors of sterol 14α-demethylase (CYP51) successfully treat fungal inf...

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Detalhes bibliográficos
Main Authors: Doyle, Patricia S., Chen, Chiung-Kuang, Johnston, Jonathan B., Hopkins, Stephanie D., Leung, Siegfried S. F., Jacobson, Matthew P., Engel, Juan C., McKerrow, James H., Podust, Larissa M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876414/
https://ncbi.nlm.nih.gov/pubmed/20385875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00281-10
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