Antifungal Pharmacokinetics and Pharmacodynamics

Por Lepak, Alexander J., Andes, David R.
Publicado no Cold Spring Harb Perspect Med (2015)

In Vivo Pharmacodynamic Target Assessment of Delafloxacin against Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumoniae in a Murine Lung Infection Model

Por Lepak, Alexander J., Andes, David R.
Publicado no Antimicrob Agents Chemother (2016)

Pharmacodynamic Target Evaluation of a Novel Oral Glucan Synthase Inhibitor, SCY-078 (MK-3118), Using an In Vivo Murine Invasive Candidiasis Model

Por Lepak, Alexander J., Marchillo, Karen, Andes, David R.
Publicado no Antimicrob Agents Chemother (2015)

Comparative Pharmacodynamics of Telavancin and Vancomycin in the Neutropenic Murine Thigh and Lung Infection Models against Staphylococcus aureus

Por Lepak, Alexander J., Zhao, Miao, Andes, David R.
Publicado no Antimicrob Agents Chemother (2017)

Pharmacodynamic Evaluation of Rezafungin (CD101) against Candida auris in the Neutropenic Mouse Invasive Candidiasis Model

Por Lepak, Alexander J., Zhao, Miao, Andes, David R.
Publicado no Antimicrob Agents Chemother (2018)

1383. In vivo Pharmacokinetic/Pharmacodynamic (PK/PD) Evaluation of NOSO-502, a First-in-Class Odilorhabdin Antibiotic, Against E. coli (EC) and K. pneumoniae (KPN) in the Murine N...

Por Zhao, Miao, Lepak, Alexander J, Andes, David R
Publicado no Open Forum Infect Dis (2018)

Optimizing Echinocandin Dosing and Susceptibility Breakpoint Determination via In Vivo Pharmacodynamic Evaluation against Candida glabrata with and without fks Mutations

Por Lepak, Alexander, Castanheira, Mariana, Diekema, Daniel, Pfaller, Michael, Andes, David
Publicado em 2012

Impact of Low Procalcitonin Results on Antibiotic Administration in Hospitalized Patients at a Tertiary Care Center

Por Brennan, Meghan B., Osterby, Kurt, Schulz, Lucas, Lepak, Alexander J.
Publicado no Infect Dis Ther (2016)

Time course global gene expression analysis of an in vivo Candida biofilm

Por Nett, Jeniel E., Lepak, Alexander J., Marchillo, Karen, Andes, David R.
Publicado em 2009

Posaconazole Pharmacodynamic Target Determination against Wild-Type and Cyp51 Mutant Isolates of Aspergillus fumigatus in an In Vivo Model of Invasive Pulmonary Aspergillosis

Por Lepak, Alexander J., Marchillo, Karen, VanHecker, Jaimie, Andes, David R.
Publicado em 2013

Impact of In Vivo Triazole and Echinocandin Combination Therapy for Invasive Pulmonary Aspergillosis: Enhanced Efficacy against Cyp51 Mutant Isolates

Por Lepak, Alexander J., Marchillo, Karen, VanHecker, Jamie, Andes, David R.
Publicado em 2013

Isavuconazole (BAL4815) Pharmacodynamic Target Determination in an In Vivo Murine Model of Invasive Pulmonary Aspergillosis against Wild-Type and cyp51 Mutant Isolates of Aspergill...

Por Lepak, Alexander J., Marchillo, Karen, VanHecker, Jamie, Andes, David R.
Publicado em 2013

In Vivo Pharmacokinetics and Pharmacodynamics of the Lantibiotic NAI-107 in a Neutropenic Murine Thigh Infection Model

Por Lepak, Alexander J., Marchillo, Karen, Craig, William A., Andes, David R.
Publicado no Antimicrob Agents Chemother (2015)

Pharmacodynamic Optimization for the Treatment of Invasive Candida auris Infection

Por Lepak, Alexander J, Zhao, Miao, Berkow, Elizabeth, Lockhart, Shawn, Andes, David R
Publicado no Open Forum Infect Dis (2017)

Comparative Pharmacodynamics of the New Oxazolidinone Tedizolid Phosphate and Linezolid in a Neutropenic Murine Staphylococcus aureus Pneumonia Model

Por Lepak, Alexander J., Marchillo, Karen, Pichereau, Solen, Craig, William A., Andes, David R.
Publicado em 2012

Isavuconazole Pharmacodynamic Target Determination for Candida Species in an In Vivo Murine Disseminated Candidiasis Model

Por Lepak, Alexander J., Marchillo, Karen, VanHecker, Jamie, Diekema, Daniel, Andes, David R.
Publicado em 2013

In Vivo Pharmacodynamic Evaluation of Omadacycline (PTK 0796) against Streptococcus pneumoniae in the Murine Pneumonia Model

Por Lepak, Alexander J., Zhao, Miao, Marchillo, Karen, VanHecker, Jamie, Andes, David R.
Publicado no Antimicrob Agents Chemother (2017)

In Vivo Pharmacodynamic Target Assessment of Eravacycline against Escherichia coli in a Murine Thigh Infection Model

Por Zhao, Miao, Lepak, Alexander J., Marchillo, Karen, VanHecker, Jamie, Andes, David R.
Publicado no Antimicrob Agents Chemother (2017)

In vivo Pharmacodynamic Evaluation of Omadacycline (PTK 0796) against Staphylococcus aureus (SA) in the Murine Thigh Infection Model

Por Lepak, Alexander J, Zhao, Miao, Marchillo, Karen, VanHecker, Jamie, Andes, David R
Publicado no Open Forum Infect Dis (2017)

In vivo Pharmacokinetic/Pharmacodynamic (PK/PD) Target Characterization of the Novel, Long Acting Echinocandin CD101 against C. albicans and C. glabrata in the Neutropenic Murine D...

Por Lepak, Alexander J, Zhao, Miao, Vanscoy, Brian, Ambrose, Paul G, Andes, David R
Publicado no Open Forum Infect Dis (2017)