Crystal structure of N-(2-{[(2E)-3-(4-chlorophenyl)-2-propenyl]- (methyl)ammonio}methylphenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide dihydrogen phosphate — methanol (1:1),...

Por Maggi Sabino, Chita Giuseppe, Bruno Claudio, Lovece Angelo, Lentini Giovanni
Publicado em 2012-06-01

Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na(+) channels in a model of myotonia induced by ATX

Por Desaphy, Jean-François, Camerino, Diana Conte, Franchini, Carlo, Lentini, Giovanni, Tortorella, Vincenzo, De Luca, Annamaria
Publicado em 1999

Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine

Por Gualdani, Roberta, Tadini-Buoninsegni, Francesco, Roselli, Mariagrazia, Defrenza, Ivana, Contino, Marialessandra, Colabufo, Nicola Antonio, Lentini, Giovanni
Publicado no Pharmacol Res Perspect (2015)

Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres

Por Carbonara, Roberta, Carocci, Alessia, Roussel, Julien, Crescenzo, Giuseppe, Buonavoglia, Canio, Franchini, Carlo, Lentini, Giovanni, Camerino, Diana Conte, Desaphy, Jean-François
Publicado no Front Pharmacol (2015)

Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential

Por De Bellis, Michela, Sanarica, Francesca, Carocci, Alessia, Lentini, Giovanni, Pierno, Sabata, Rolland, Jean-François, Conte Camerino, Diana, De Luca, Annamaria
Publicado no Front Pharmacol (2018)

Molecular Insights into the Local Anesthetic Receptor within Voltage-Gated Sodium Channels Using Hydroxylated Analogs of Mexiletine

Por Desaphy, Jean-François, Dipalma, Antonella, Costanza, Teresa, Carbonara, Roberta, Dinardo, Maria Maddalena, Catalano, Alessia, Carocci, Alessia, Lentini, Giovanni, Franchini, Carlo, Camerino, Diana Conte
Publicado em 2012

Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo

Por Talon, Sophie, De Luca, Annamaria, De Bellis, Michela, Desaphy, Jean-François, Lentini, Giovanni, Scilimati, Antonio, Corbo, Filomena, Franchini, Carlo, Tortorella, Paolo, Jockusch, Harald, Conte Camerino, Diana
Publicado em 2001

Combined Modifications of Mexiletine Pharmacophores for New Lead Blockers of Na(v)1.4 Channels

Por De Bellis, Michela, De Luca, Annamaria, Desaphy, Jean F., Carbonara, Roberta, Heiny, Judith A., Kennedy, Ann, Carocci, Alessia, Cavalluzzi, Maria M., Lentini, Giovanni, Franchini, Carlo, Conte Camerino, Diana
Publicado em 2013