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Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na(+) channels in a model of myotonia induced by ATX
1. The antiarrhythmic drug mexiletine (Mex) is also used against myotonia. Searching for a more efficient drug, a new compound (Me5) was synthesized substituting the methyl group on the chiral carbon atom of Mex by an isopropyl group. Effects of Me5 on Na(+) channels were compared to those of Mex in...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
1999
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1571747/ https://ncbi.nlm.nih.gov/pubmed/10578128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702901 |
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