Yüklüyor......
Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na(+) channels in a model of myotonia induced by ATX
1. The antiarrhythmic drug mexiletine (Mex) is also used against myotonia. Searching for a more efficient drug, a new compound (Me5) was synthesized substituting the methyl group on the chiral carbon atom of Mex by an isopropyl group. Effects of Me5 on Na(+) channels were compared to those of Mex in...
Kaydedildi:
| Asıl Yazarlar: | , , , , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
1999
|
| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1571747/ https://ncbi.nlm.nih.gov/pubmed/10578128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702901 |
| Etiketler: |
Etiketle
Etiket eklenmemiş, İlk siz ekleyin!
|