Molecular Insights into the Local Anesthetic Receptor within Voltage-Gated Sodium Channels Using Hydroxylated Analogs of Mexiletine

We previously showed that the β-adrenoceptor modulators, clenbuterol and propranolol, directly blocked voltage-gated sodium channels, whereas salbutamol and nadolol did not (Desaphy et al., 2003), suggesting the presence of two hydroxyl groups on the aromatic moiety of the drugs as a molecular requi...

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Detalhes bibliográficos
Main Authors: Desaphy, Jean-François, Dipalma, Antonella, Costanza, Teresa, Carbonara, Roberta, Dinardo, Maria Maddalena, Catalano, Alessia, Carocci, Alessia, Lentini, Giovanni, Franchini, Carlo, Camerino, Diana Conte
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Research Foundation 2012
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279704/
https://ncbi.nlm.nih.gov/pubmed/22403541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2012.00017
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