Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres

Voltage-gated sodium channels are known to play a pivotal role in perception and transmission of pain sensations. Gain-of-function mutations in the genes encoding the peripheral neuronal sodium channels, hNav1.7–1.9, cause human painful diseases. Thus while treatment of chronic pain remains an unmet...

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Publicat a:Front Pharmacol
Autors principals: Carbonara, Roberta, Carocci, Alessia, Roussel, Julien, Crescenzo, Giuseppe, Buonavoglia, Canio, Franchini, Carlo, Lentini, Giovanni, Camerino, Diana Conte, Desaphy, Jean-François
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2015
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513211/
https://ncbi.nlm.nih.gov/pubmed/26257653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00155
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