Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide

BACKGROUND AND PURPOSE: Pilsicainide, an anti-arrhythmic drug used in Japan, is described as a pure sodium channel blocker. We examined the mechanisms by which it is able to block open channels, because these properties may be especially useful to reduce hyperexcitability in pathologies characterize...

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Detalhes bibliográficos
Main Authors: Desaphy, J-F, Dipalma, A, Costanza, T, Bruno, C, Lentini, G, Franchini, C, George, AL, Camerino, D Conte
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938822/
https://ncbi.nlm.nih.gov/pubmed/20590641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00816.x
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