Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents

BACKGROUND AND PURPOSE: Mexiletine (Mex), an orally effective antiarrhythmic agent used to treat ventricular arrhythmias, has also been found to be effective for myotonia and neuropathic pain. It is extensively metabolized in humans but little information exists about the pharmacodynamic properties...

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Detalhes bibliográficos
Main Authors: De Bellis, M, De Luca, A, Rana, F, Cavalluzzi, M M, Catalano, A, Lentini, G, Franchini, C, Tortorella, V, Conte Camerino, D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014276/
https://ncbi.nlm.nih.gov/pubmed/16921388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706867
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