Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents

BACKGROUND AND PURPOSE: Mexiletine (Mex), an orally effective antiarrhythmic agent used to treat ventricular arrhythmias, has also been found to be effective for myotonia and neuropathic pain. It is extensively metabolized in humans but little information exists about the pharmacodynamic properties...

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Dettagli Bibliografici
Autori principali: De Bellis, M, De Luca, A, Rana, F, Cavalluzzi, M M, Catalano, A, Lentini, G, Franchini, C, Tortorella, V, Conte Camerino, D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2006
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014276/
https://ncbi.nlm.nih.gov/pubmed/16921388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706867
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