Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential

Mexiletine (Mex) has been recently appointed as an orphan-drug in myotonic-syndromes, being a potent use-dependent blocker of skeletal-muscle sodium channels (Na(V)1.4). Available evidences about a potential anti-oxidant effect of Mex and its tetramethyl-pyrroline-derivatives in vivo, suggest the po...

Full description

Saved in:
Bibliographic Details
Published in:Front Pharmacol
Main Authors: De Bellis, Michela, Sanarica, Francesca, Carocci, Alessia, Lentini, Giovanni, Pierno, Sabata, Rolland, Jean-François, Conte Camerino, Diana, De Luca, Annamaria
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770958/
https://ncbi.nlm.nih.gov/pubmed/29379434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00907
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items