Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo

1. Searching for the structural requirements improving the potency and the stereoselectivity of Na(+) channel blockers as antimyotonic agents, new derivatives of tocainide, in which the chiral carbon atom is constrained in a rigid α-proline or pyrrolo-imidazolic cycle, were synthesized as pure enant...

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Main Authors: Talon, Sophie, De Luca, Annamaria, De Bellis, Michela, Desaphy, Jean-François, Lentini, Giovanni, Scilimati, Antonio, Corbo, Filomena, Franchini, Carlo, Tortorella, Paolo, Jockusch, Harald, Conte Camerino, Diana
Format: Artigo
Language:Inglês
Published: 2001
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573071/
https://ncbi.nlm.nih.gov/pubmed/11724759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704366
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