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Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine

Mexiletine is a sodium channel blocker, primarily used in the treatment of ventricular arrhythmias. Moreover, recent studies have demonstrated its therapeutic value to treat myotonic syndromes and to relieve neuropathic pain. The present study aims at investigating the direct blockade of hERG potass...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Gualdani, Roberta, Tadini-Buoninsegni, Francesco, Roselli, Mariagrazia, Defrenza, Ivana, Contino, Marialessandra, Colabufo, Nicola Antonio, Lentini, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618635/
https://ncbi.nlm.nih.gov/pubmed/26516576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.160
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