Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine

Mexiletine is a sodium channel blocker, primarily used in the treatment of ventricular arrhythmias. Moreover, recent studies have demonstrated its therapeutic value to treat myotonic syndromes and to relieve neuropathic pain. The present study aims at investigating the direct blockade of hERG potass...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Pharmacol Res Perspect
Egile Nagusiak: Gualdani, Roberta, Tadini-Buoninsegni, Francesco, Roselli, Mariagrazia, Defrenza, Ivana, Contino, Marialessandra, Colabufo, Nicola Antonio, Lentini, Giovanni
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley & Sons, Ltd 2015
Gaiak:
Original Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618635/
https://ncbi.nlm.nih.gov/pubmed/26516576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.160
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