Stem cells, cancer and MUSASHI in blood and guts

Por Kharas, Michael G., Lengner, Christopher J.
Publicado no Trends Cancer (2017)

Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish

Por Valvezan, Alexander J., Huang, Jian, Lengner, Christopher J., Pack, Michael, Klein, Peter S.
Publicado em 2014

Mouse Label-Retaining Cells Are Molecularly And Functionally Distinct From Reserve Intestinal Stem Cells

Por Li, Ning, Nakauka-Ddamba, Angela, Tobias, John, Jensen, Shane T., Lengner, Christopher J.
Publicado no Gastroenterology (2016)

Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells

Por Brambrink, Tobias, Foreman, Ruth, Welstead, G. Grant, Lengner, Christopher J., Wernig, Marius, Suh, Heikyung, Jaenisch, Rudolf
Publicado em 2008

A System for Genome-Wide Histone Variant Dynamics In ES Cells Reveals Dynamic MacroH2A2 Replacement at Promoters

Por Yildirim, Ozlem, Hung, Jui-Hung, Cedeno, Ryan J., Weng, Zhiping, Lengner, Christopher J., Rando, Oliver J.
Publicado em 2014

Heterogeneity in readouts of canonical Wnt pathway activity within intestinal crypts

Por Li, Ning, Yousefi, Maryam, Nakauka-Ddamba, Angela, Tobias, John W., Jensen, Shane T., Morrisey, Edward E., Lengner, Christopher J.
Publicado no Dev Dyn (2016)

Single-Cell Analysis of Proxy Reporter Allele-Marked Epithelial Cells Establishes Intestinal Stem Cell Hierarchy

Por Li, Ning, Yousefi, Maryam, Nakauka-Ddamba, Angela, Jain, Rajan, Tobias, John, Epstein, Jonathan A., Jensen, Shane T., Lengner, Christopher J.
Publicado no Stem Cell Reports (2014)

A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types

Por Wernig, Marius, Lengner, Christopher J, Hanna, Jacob, Lodato, Michael A, Steine, Eveline, Foreman, Ruth, Staerk, Judith, Markoulaki, Styliani, Jaenisch, Rudolf
Publicado em 2008

Direct cell reprogramming is a stochastic process amenable to acceleration

Por Hanna, Jacob, Saha, Krishanu, Pando, Bernardo, van Zon, Jeroen, Lengner, Christopher J., Creyghton, Menno P., van Oudenaarden, Alexander, Jaenisch, Rudolf
Publicado em 2009

Post-transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22

Por Yuan, Shukai, Li, Feifei, Meng, Qingyong, Zhao, Yiqiang, Chen, Lei, Zhang, Hongquan, Xue, Lixiang, Zhang, Xiuqing, Lengner, Christopher, Yu, Zhengquan
Publicado no PLoS Genet (2015)

The histone variant macroH2A confers functional robustness to the intestinal stem cell compartment

Por Cedeno, Ryan James, Nakauka-Ddamba, Angela, Yousefi, Maryam, Sterling, Stephanie, Leu, Nicolae Adrian, Li, Ning, Pehrson, John R., Lengner, Christopher Joachim
Publicado no PLoS One (2017)

Oct4 expression is not required for mouse somatic stem cell self-renewal

Por Lengner, Christopher J, Camargo, Fernando D, Hochedlinger, Konrad, Welstead, G Grant, Zaidi, Samir, Gokhale, Sumita, Scholer, Hans R, Tomilin, Alexey, Jaenisch, Rudolf
Publicado em 2007

Msi RNA-binding proteins control reserve intestinal stem cell quiescence

Por Yousefi, Maryam, Li, Ning, Nakauka-Ddamba, Angela, Wang, Shan, Davidow, Kimberly, Schoenberger, Jenna, Yu, Zhengquan, Jensen, Shane T., Kharas, Michael G., Lengner, Christopher J.
Publicado no J Cell Biol (2016)

Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs

Por Hanna, Jacob, Cheng, Albert W., Saha, Krishanu, Kim, Jongpil, Lengner, Christopher J., Soldner, Frank, Cassady, John P., Muffat, Julien, Carey, Bryce W., Jaenisch, Rudolf
Publicado em 2010

Osteoblast differentiation and skeletal development are regulated by Mdm2–p53 signaling

Por Lengner, Christopher J., Steinman, Heather A., Gagnon, James, Smith, Thomas W., Henderson, Janet E., Kream, Barbara E., Stein, Gary S., Lian, Jane B., Jones, Stephen N.
Publicado em 2006

Transgenic Mice with Defined Combinations of Drug Inducible Reprogramming Factors

Por Markoulaki, Styliani, Hanna, Jacob, Beard, Caroline, Carey, Bryce W., Cheng, Albert W., Lengner, Christopher J., Dausman, Jessica A., Fu, Dongdong, Gao, Qing, Wu, Su, Cassady, John P., Jaenisch, Rudolf
Publicado em 2009

Metastable Pluripotent States in NOD Mouse Derived ES Cells

Por Hanna, Jacob, Markoulaki, Styliani, Mitalipova, Maisam, Cheng, Albert W., Cassady, John P., Staerk, Judith, Carey, Bryce W., Lengner, Christopher J., Foreman, Ruth, Love, Jennifer, Gao, Qing, Kim, Jongpil, Jaenisch, Rudolf
Publicado em 2009

Functional integration of dopaminergic neurons directly converted from mouse fibroblasts

Por Kim, Jongpil, Su, Susan C., Wang, Haoyi, Cheng, Albert W., Cassady, John P., Lodato, Michael A., Lengner, Christopher J., Chung, Chee-Yeun, Dawlaty, Meelad M., Tsai, Li-Huei, Jaenisch, Rudolf
Publicado em 2011

Transformation of the intestinal epithelium by the MSI2 RNA binding protein

Por Wang, Shan, Li, Ning, Yousefi, Maryam, Nakauka-Ddamba, Angela, Li, Fan, Parada, Kimberly, Rao, Shilpa, Minuesa, Gerard, Katz, Yarden, Gregory, Brian D., Kharas, Michael G., Yu, Zhengquan, Lengner, Christopher J.
Publicado no Nat Commun (2015)

Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche

Por Yang, Ting-Lin B., Chen, Qijun, Deng, Jennifer T., Jagannathan, Geetha, Tobias, John W., Schultz, David C., Wang, Shan, Lengner, Christopher J., Rustgi, Anil K., Lynch, John P., Johnson, F. Brad
Publicado no Nat Commun (2017)