Osteoblast differentiation and skeletal development are regulated by Mdm2–p53 signaling

Mdm2 is required to negatively regulate p53 activity at the peri-implantation stage of early mouse development. However, the absolute requirement for Mdm2 throughout embryogenesis and in organogenesis is unknown. To explore Mdm2–p53 signaling in osteogenesis, Mdm2-conditional mice were bred with Col...

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Detalhes bibliográficos
Main Authors: Lengner, Christopher J., Steinman, Heather A., Gagnon, James, Smith, Thomas W., Henderson, Janet E., Kream, Barbara E., Stein, Gary S., Lian, Jane B., Jones, Stephen N.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063734/
https://ncbi.nlm.nih.gov/pubmed/16533949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200508130
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