Antibacterials Developed to Target a Single Organism: Mechanisms and Frequencies of Reduced Susceptibility to the Novel Anti-Clostridium difficile Compounds Fidaxomicin and LFF571

著者: Leeds, Jennifer A.
出版年 Cold Spring Harb Perspect Med (2016)

Subinhibitory Concentrations of LFF571 Reduce Toxin Production by Clostridium difficile

著者: Sachdeva, Meena, Leeds, Jennifer A.
出版年 Antimicrob Agents Chemother (2015)

Pseudomonas aeruginosa Directly Shunts β-Oxidation Degradation Intermediates into De Novo Fatty Acid Biosynthesis

著者: Yuan, Yanqiu, Leeds, Jennifer A., Meredith, Timothy C.
出版事項 2012

Fatty Acid Biosynthesis in Pseudomonas aeruginosa Is Initiated by the FabY Class of β-Ketoacyl Acyl Carrier Protein Synthases

著者: Yuan, Yanqiu, Sachdeva, Meena, Leeds, Jennifer A., Meredith, Timothy C.
出版事項 2012

Deletion of the β-Acetoacetyl Synthase FabY in Pseudomonas aeruginosa Induces Hypoacylation of Lipopolysaccharide and Increases Antimicrobial Susceptibility

著者: Six, David A., Yuan, Yanqiu, Leeds, Jennifer A., Meredith, Timothy C.
出版事項 2014

Subcellular Chemical Imaging of Antibiotics in Single Bacteria Using C(60)-Secondary Ion Mass Spectrometry

著者: Tian, Hua, Six, David A., Krucker, Thomas, Leeds, Jennifer A., Winograd, Nicholas
出版年 Anal Chem (2017)

DegS and YaeL participate sequentially in the cleavage of RseA to activate the σ(E)-dependent extracytoplasmic stress response

著者: Alba, Benjamin M., Leeds, Jennifer A., Onufryk, Christina, Lu, Chi Zen, Gross, Carol A.
出版事項 2002

Efficacy of LFF571 in a Hamster Model of Clostridium difficile Infection

著者: Trzasko, Anna, Leeds, Jennifer A., Praestgaard, Jens, LaMarche, Matthew J., McKenney, David
出版事項 2012

A First-in-Human, Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study To Assess the Safety and Tolerability of LFF571 in Healthy Volunteers

著者: Ting, Lillian S. L., Praestgaard, Jens, Grunenberg, Nicole, Yang, Jenny C., Leeds, Jennifer A., Pertel, Peter
出版事項 2012

Pharmacokinetics of LFF571 and Vancomycin in Patients with Moderate Clostridium difficile Infections

著者: Bhansali, Suraj G., Mullane, Kathleen, Ting, Lillian S. L., Leeds, Jennifer A., Dabovic, Kristina, Praestgaard, Jens, Pertel, Peter
出版年 Antimicrob Agents Chemother (2015)

Multicenter, Randomized Clinical Trial To Compare the Safety and Efficacy of LFF571 and Vancomycin for Clostridium difficile Infections

著者: Mullane, Kathleen, Lee, Christine, Bressler, Adam, Buitrago, Martha, Weiss, Karl, Dabovic, Kristina, Praestgaard, Jens, Leeds, Jennifer A., Blais, Johanne, Pertel, Peter
出版年 Antimicrob Agents Chemother (2015)

In Vitro Activity of LYS228, a Novel Monobactam Antibiotic, against Multidrug-Resistant Enterobacteriaceae

著者: Blais, Johanne, Lopez, Sara, Li, Cindy, Ruzin, Alexey, Ranjitkar, Srijan, Dean, Charles R., Leeds, Jennifer A., Casarez, Anthony, Simmons, Robert L., Reck, Folkert
出版年 Antimicrob Agents Chemother (2018)

Reduced Susceptibility of Haemophilus influenzae to the Peptide Deformylase Inhibitor LBM415 Can Result from Target Protein Overexpression Due to Amplified Chromosomal def Gene Cop...

著者: Dean, Charles R., Narayan, Shubha, Richards, Joel, Daigle, Denis M., Esterow, Stacy, Leeds, Jennifer A., Kamp, Heather, Puyang, Xiaoling, Wiedmann, Brigitte, Mueller, Dieter, Voshol, Hans, van Oostrum, Jan, Wall, Daniel, Koehn, James, Dzink-Fox, JoAnn, Ryder, Neil S.
出版事項 2007