Antibacterials Developed to Target a Single Organism: Mechanisms and Frequencies of Reduced Susceptibility to the Novel Anti-Clostridium difficile Compounds Fidaxomicin and LFF571

Por Leeds, Jennifer A.
Publicado no Cold Spring Harb Perspect Med (2016)

Subinhibitory Concentrations of LFF571 Reduce Toxin Production by Clostridium difficile

Por Sachdeva, Meena, Leeds, Jennifer A.
Publicado no Antimicrob Agents Chemother (2015)

Pseudomonas aeruginosa Directly Shunts β-Oxidation Degradation Intermediates into De Novo Fatty Acid Biosynthesis

Por Yuan, Yanqiu, Leeds, Jennifer A., Meredith, Timothy C.
Publicado em 2012

Fatty Acid Biosynthesis in Pseudomonas aeruginosa Is Initiated by the FabY Class of β-Ketoacyl Acyl Carrier Protein Synthases

Por Yuan, Yanqiu, Sachdeva, Meena, Leeds, Jennifer A., Meredith, Timothy C.
Publicado em 2012

Deletion of the β-Acetoacetyl Synthase FabY in Pseudomonas aeruginosa Induces Hypoacylation of Lipopolysaccharide and Increases Antimicrobial Susceptibility

Por Six, David A., Yuan, Yanqiu, Leeds, Jennifer A., Meredith, Timothy C.
Publicado em 2014

DegS and YaeL participate sequentially in the cleavage of RseA to activate the σ(E)-dependent extracytoplasmic stress response

Por Alba, Benjamin M., Leeds, Jennifer A., Onufryk, Christina, Lu, Chi Zen, Gross, Carol A.
Publicado em 2002

Efficacy of LFF571 in a Hamster Model of Clostridium difficile Infection

Por Trzasko, Anna, Leeds, Jennifer A., Praestgaard, Jens, LaMarche, Matthew J., McKenney, David
Publicado em 2012

A First-in-Human, Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study To Assess the Safety and Tolerability of LFF571 in Healthy Volunteers

Por Ting, Lillian S. L., Praestgaard, Jens, Grunenberg, Nicole, Yang, Jenny C., Leeds, Jennifer A., Pertel, Peter
Publicado em 2012

Pharmacokinetics of LFF571 and Vancomycin in Patients with Moderate Clostridium difficile Infections

Por Bhansali, Suraj G., Mullane, Kathleen, Ting, Lillian S. L., Leeds, Jennifer A., Dabovic, Kristina, Praestgaard, Jens, Pertel, Peter
Publicado no Antimicrob Agents Chemother (2015)

Multicenter, Randomized Clinical Trial To Compare the Safety and Efficacy of LFF571 and Vancomycin for Clostridium difficile Infections

Por Mullane, Kathleen, Lee, Christine, Bressler, Adam, Buitrago, Martha, Weiss, Karl, Dabovic, Kristina, Praestgaard, Jens, Leeds, Jennifer A., Blais, Johanne, Pertel, Peter
Publicado no Antimicrob Agents Chemother (2015)

Reduced Susceptibility of Haemophilus influenzae to the Peptide Deformylase Inhibitor LBM415 Can Result from Target Protein Overexpression Due to Amplified Chromosomal def Gene Cop...

Por Dean, Charles R., Narayan, Shubha, Richards, Joel, Daigle, Denis M., Esterow, Stacy, Leeds, Jennifer A., Kamp, Heather, Puyang, Xiaoling, Wiedmann, Brigitte, Mueller, Dieter, Voshol, Hans, van Oostrum, Jan, Wall, Daniel, Koehn, James, Dzink-Fox, JoAnn, Ryder, Neil S.
Publicado em 2007