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A First-in-Human, Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study To Assess the Safety and Tolerability of LFF571 in Healthy Volunteers

Clostridium difficile is the leading cause of hospital-acquired infectious diarrhea. LFF571 is a novel inhibitor of the prokaryotic translation elongation factor Tu and is active against a range of bacterial species, including C. difficile. This first-in-human study investigated the safety and pharm...

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Autori principali: Ting, Lillian S. L., Praestgaard, Jens, Grunenberg, Nicole, Yang, Jenny C., Leeds, Jennifer A., Pertel, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486596/
https://ncbi.nlm.nih.gov/pubmed/22964250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00867-12
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