HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome

by Lai, Rachel P. J., Meintjes, Graeme, Wilkinson, Robert J.
Published in Semin Immunopathol (2015)

Inflammasome Activation Underlying Central Nervous System Deterioration in HIV-Associated Tuberculosis

by Marais, Suzaan, Lai, Rachel P. J., Wilkinson, Katalin A., Meintjes, Graeme, O’Garra, Anne, Wilkinson, Robert J.
Published in J Infect Dis (2017)

Nef Decreases HIV-1 Sensitivity to Neutralizing Antibodies that Target the Membrane-proximal External Region of TMgp41

by Lai, Rachel P.J., Yan, Jin, Heeney, Jonathan, McClure, Myra O., Göttlinger, Heinrich, Luban, Jeremy, Pizzato, Massimo
Published 2011

Effect of prednisolone on inflammatory markers in pericardial tuberculosis: A pilot study

by Shenje, Justin, Lai, Rachel P., Ross, Ian L., Mayosi, Bongani M., Wilkinson, Robert J., Ntsekhe, Mpiko, Wilkinson, Katalin A.
Published in Int J Cardiol Heart Vasc (2017)

Corticosteroids as an adjunct to tuberculosis therapy

by Schutz, Charlotte, Davis, Angharad G, Sossen, Bianca, Lai, Rachel P-J, Ntsekhe, Mpiko, Harley, Yolande XR, Wilkinson, Robert J
Published in Expert Rev Respir Med (2018)

A Rab20-Dependent Membrane Trafficking Pathway Controls M. tuberculosis Replication by Regulating Phagosome Spaciousness and Integrity

by Schnettger, Laura, Rodgers, Angela, Repnik, Urska, Lai, Rachel P., Pei, Gang, Verdoes, Martijn, Wilkinson, Robert J., Young, Douglas B., Gutierrez, Maximiliano G.
Published in Cell Host Microbe (2017)

Mycobacterium tuberculosis cords within lymphatic endothelial cells to evade host immunity

by Lerner, Thomas R., Queval, Christophe J., Lai, Rachel P., Russell, Matthew R.G., Fearns, Antony, Greenwood, Daniel J., Collinson, Lucy, Wilkinson, Robert J., Gutierrez, Maximiliano G.
Published in JCI Insight (2020)

Complement pathway gene activation and rising circulating immune complexes characterize early disease in HIV-associated tuberculosis

by Esmail, Hanif, Lai, Rachel P., Lesosky, Maia, Wilkinson, Katalin A., Graham, Christine M., Horswell, Stuart, Coussens, Anna K., Barry, Clifton E., O’Garra, Anne, Wilkinson, Robert J.
Published in Proc Natl Acad Sci U S A (2018)

Molecular Evolution Analysis of the Human Immunodeficiency Virus Type 1 Envelope in Simian/Human Immunodeficiency Virus-Infected Macaques: Implications for Challenge Dose Selection

by Varela, Mariana, Landskron, Lisa, Lai, Rachel P. J., McKinley, Trevelyan J., Bogers, Willy M., Verschoor, Ernst J., Dubbes, Rob, Barnett, Susan W., Frost, Simon D. W., Heeney, Jonathan L.
Published 2011

Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity

by Rohlwink, Ursula K., Figaji, Anthony, Wilkinson, Katalin A., Horswell, Stuart, Sesay, Abdul K., Deffur, Armin, Enslin, Nico, Solomons, Regan, Van Toorn, Ronald, Eley, Brian, Levin, Michael, Wilkinson, Robert J., Lai, Rachel P. J.
Published in Nat Commun (2019)

Genetic Imprint of Vaccination on Simian/Human Immunodeficiency Virus Type 1 Transmitted Viral Genomes in Rhesus Macaques

by Varela, Mariana, Verschoor, Ernst, Lai, Rachel P. J., Hughes, Joseph, Mooj, Petra, McKinley, Trevelyan J., Fitzmaurice, Timothy J., Landskron, Lisa, Willett, Brian J., Frost, Simon D. W., Bogers, Willy M., Heeney, Jonathan L.
Published 2013

Mixed Adjuvant Formulations Reveal a New Combination That Elicit Antibody Response Comparable to Freund's Adjuvants

by Lai, Rachel P. J., Seaman, Michael S., Tonks, Paul, Wegmann, Frank, Seilly, David J., Frost, Simon D. W., LaBranche, Celia C., Montefiori, David C., Dey, Antu K., Srivastava, Indresh K., Sattentau, Quentin, Barnett, Susan W., Heeney, Jonathan L.
Published 2012

HIV–tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling

by Lai, Rachel P. J., Meintjes, Graeme, Wilkinson, Katalin A., Graham, Christine M., Marais, Suzaan, Van der Plas, Helen, Deffur, Armin, Schutz, Charlotte, Bloom, Chloe, Munagala, Indira, Anguiano, Esperanza, Goliath, Rene, Maartens, Gary, Banchereau, Jacques, Chaussabel, Damien, O'Garra, Anne, Wilkinson, Robert J.
Published in Nat Commun (2015)

A Fusion Intermediate gp41 Immunogen Elicits Neutralizing Antibodies to HIV-1

by Lai, Rachel P. J., Hock, Miriam, Radzimanowski, Jens, Tonks, Paul, Hulsik, David Lutje, Effantin, Gregory, Seilly, David J., Dreja, Hanna, Kliche, Alexander, Wagner, Ralf, Barnett, Susan W., Tumba, Nancy, Morris, Lynn, LaBranche, Celia C., Montefiori, David C., Seaman, Michael S., Heeney, Jonathan L., Weissenhorn, Winfried
Published 2014

Interleukin 27R regulates CD4(+) T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection

by Torrado, Egidio, Fountain, Jeffrey J., Liao, Mingfeng, Tighe, Michael, Reiley, William W., Lai, Rachel P., Meintjes, Graeme, Pearl, John E., Chen, Xinchun, Zak, Daniel E., Thompson, Ethan G., Aderem, Alan, Ghilardi, Nico, Solache, Alejandra, McKinstry, K. Kai, Strutt, Tara M., Wilkinson, Robert J., Swain, Susan L., Cooper, Andrea M.
Published in J Exp Med (2015)

Study protocol for a phase 2A trial of the safety and tolerability of increased dose rifampicin and adjunctive linezolid, with or without aspirin, for HIV-associated tuberculous me...

by Davis, Angharad G., Wasserman, Sean, Maxebengula, Mpumi, Stek, Cari, Bremer, Marise, Daroowala, Remy, Aziz, Saalikha, Goliath, Rene, Stegmann, Stephani, Koekemoer, Sonya, Jackson, Amanda, Lai Sai, Louise, Kadernani, Yakub, Sihoyiya, Thandi, Liang, C.Jason, Dodd, Lori, Denti, Paolo, Crede, Thomas, Naude, Jonathan, Szymanski, Patryk, Vallie, Yakoob, Banderker, Ismail, Moosa, Shiraz, Raubenheimer, Peter, Lai, Rachel P.J., Joska, John, Nightingale, Sam, Dreyer, Anna, Wahl, Gerda, Offiah, Curtis, Vorster, Isak, Candy, Sally, Robertson, Frances, Meintjes, Ernesta, Maartens, Gary, Black, John, Meintjes, Graeme, Wilkinson, Robert J.
Published in Wellcome Open Res (2021)