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Nef Decreases HIV-1 Sensitivity to Neutralizing Antibodies that Target the Membrane-proximal External Region of TMgp41

Primate lentivirus nef is required for sustained virus replication in vivo and accelerated progression to AIDS. While exploring the mechanism by which Nef increases the infectivity of cell-free virions, we investigated a functional link between Nef and Env. Since we failed to detect an effect of Nef...

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Autores principales: Lai, Rachel P.J., Yan, Jin, Heeney, Jonathan, McClure, Myra O., Göttlinger, Heinrich, Luban, Jeremy, Pizzato, Massimo
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3240605/
https://ncbi.nlm.nih.gov/pubmed/22194689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002442
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