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HIV-1 Nef Responsiveness is Determined by Env Variable Regions Involved in Trimer Association and Correlates with Neutralization Sensitivity

HIV-1 Nef and the unrelated MLV glycoGag similarly enhance the infectivity of HIV-1 virions. We now show that the effects of Nef and glycoGag are similarly determined by variable regions of HIV-1 gp120 that control Env trimer association and neutralization sensitivity. Whereas neutralization-sensiti...

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Hlavní autoři: Usami, Yoshiko, Göttlinger, Heinrich
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864691/
https://ncbi.nlm.nih.gov/pubmed/24209751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.09.028
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