A Novel Strategy for Inducing Enhanced Mucosal HIV-1 Antibody Responses in an Anti-Inflammatory Environment

por Wegmann, Frank, Krashias, George, Lühn, Kerstin, Laamanen, Karoliina, Vieira, Sueli, Jeffs, Simon A., Shattock, Robin J., Sattentau, Quentin J.
Publicado 2011

Coronavirus-Specific Antibody Cross Reactivity in Rhesus Macaques following SARS-CoV-2 Vaccination and Infection

por Jacob-Dolan, Catherine, Feldman, Jared, McMahan, Katherine, Yu, Jingyou, Zahn, Roland, Wegmann, Frank, Schuitemaker, Hanneke, Schmidt, Aaron G., Barouch, Dan H.
Publicado en J Virol (2021)

Carnauba wax nanoparticles enhance strong systemic and mucosal cellular and humoral immune responses to HIV-gp140 antigen

por Arias, Mauricio A., Loxley, Andrew, Eatmon, Christy, Van Roey, Griet, Fairhurst, David, Mitchnick, Mark, Dash, Philip, Cole, Tom, Wegmann, Frank, Sattentau, Quentin, Shattock, Robin
Publicado 2011

The Carbomer-Lecithin Adjuvant Adjuplex Has Potent Immunoactivating Properties and Elicits Protective Adaptive Immunity against Influenza Virus Challenge in Mice

por Wegmann, Frank, Moghaddam, Amin E., Schiffner, Torben, Gartlan, Kate H., Powell, Timothy J., Russell, Rebecca A., Baart, Matthijs, Carrow, Emily W., Sattentau, Quentin J.
Publicado en Clin Vaccine Immunol (2015)

Sterile inflammation induced by Carbopol elicits robust adaptive immune responses in the absence of pathogen-associated molecular patterns

por Gartlan, Kate H., Krashias, George, Wegmann, Frank, Hillson, William R., Scherer, Erin M., Greenberg, Philip D., Eisenbarth, Stephanie C., Moghaddam, Amin E., Sattentau, Quentin J.
Publicado en Vaccine (2016)

Nasal Immunization Confers High Avidity Neutralizing Antibody Response and Immunity to Primary and Recurrent Genital Herpes in Guinea Pigs

por Persson, Josefine, Zhang, Yuan, Olafsdottir, Thorunn A., Thörn, Karolina, Cairns, Tina M., Wegmann, Frank, Sattentau, Quentin J., Eisenberg, Roselyn J., Cohen, Gary H., Harandi, Ali M.
Publicado en Front Immunol (2016)

Similar Epitope Specificities of IgG and IgA Antibodies Elicited by Ad26 Vector Prime, Env Protein Boost Immunizations in Rhesus Monkeys

por Kang, Zi Han, Bricault, Christine A., Borducchi, Erica N., Stephenson, Kathryn E., Seaman, Michael S., Pau, Maria, Schuitemaker, Hanneke, van Manen, Danielle, Wegmann, Frank, Barouch, Dan H.
Publicado en J Virol (2018)

ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability

por Wegmann, Frank, Petri, Björn, Khandoga, Alexander Georg, Moser, Christian, Khandoga, Andrej, Volkery, Stefan, Li, Hang, Nasdala, Ines, Brandau, Oliver, Fässler, Reinhard, Butz, Stefan, Krombach, Fritz, Vestweber, Dietmar
Publicado 2006

Mixed Adjuvant Formulations Reveal a New Combination That Elicit Antibody Response Comparable to Freund's Adjuvants

por Lai, Rachel P. J., Seaman, Michael S., Tonks, Paul, Wegmann, Frank, Seilly, David J., Frost, Simon D. W., LaBranche, Celia C., Montefiori, David C., Dey, Antu K., Srivastava, Indresh K., Sattentau, Quentin, Barnett, Susan W., Heeney, Jonathan L.
Publicado 2012

A vaccine-induced gene expression signature correlates with protection against SIV and HIV in multiple trials

por Ehrenberg, Philip K., Shangguan, Shida, Issac, Biju, Alter, Galit, Geretz, Aviva, Izumi, Taisuke, Bryant, Christopher, Eller, Michael A., Wegmann, Frank, Apps, Richard, Creegan, Matthew, Bolton, Diane L., Sekaly, Rafick P., Robb, Merlin L., Gramzinski, Robert A., Pau, Maria G., Schuitemaker, Hanneke, Barouch, Dan H., Michael, Nelson L., Thomas, Rasmi
Publicado en Sci Transl Med (2019)

Polyethyleneimine is a potent mucosal adjuvant for glycoproteins with innate and adaptive immune activating properties

por Wegmann, Frank, Gartlan, Kate H, Harandi, Ali M, Brinckmann, Sarah A, Coccia, Margherita, Hillson, William R, Kok, Wai Ling, Cole, Suzanne, Ho, Ling-Pei, Lambe, Teresa, Puthia, Manoj, Svanborg, Catharina, Scherer, Erin M, Krashias, George, Williams, Adam, Blattman, Joseph N, Greenberg, Philip D, Flavell, Richard A, Moghaddam, Amin E, Sheppard, Neil C, Sattentau, Quentin J
Publicado 2012

Safety and immunogenicity of two heterologous HIV vaccine regimens in healthy, HIV-uninfected adults (TRAVERSE): a randomised, parallel-group, placebo-controlled, double-blind, pha...

por Baden, Lindsey R, Stieh, Daniel J, Sarnecki, Michal, Walsh, Stephen R, Tomaras, Georgia D, Kublin, James G, McElrath, M Juliana, Alter, Galit, Ferrari, Guido, Montefiori, David, Mann, Philipp, Nijs, Steven, Callewaert, Katleen, Goepfert, Paul, Edupuganti, Srilatha, Karita, Etienne, Langedijk, Johannes P, Wegmann, Frank, Corey, Lawrence, Pau, Maria G, Barouch, Dan H, Schuitemaker, Hanneke, Tomaka, Frank
Publicado en Lancet HIV (2020)

Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses

por Bos, Rinke, Rutten, Lucy, van der Lubbe, Joan E. M., Bakkers, Mark J. G., Hardenberg, Gijs, Wegmann, Frank, Zuijdgeest, David, de Wilde, Adriaan H., Koornneef, Annemart, Verwilligen, Annemiek, van Manen, Danielle, Kwaks, Ted, Vogels, Ronald, Dalebout, Tim J., Myeni, Sebenzile K., Kikkert, Marjolein, Snijder, Eric J., Li, Zhenfeng, Barouch, Dan H., Vellinga, Jort, Langedijk, Johannes P. M., Zahn, Roland C., Custers, Jerome, Schuitemaker, Hanneke
Publicado en NPJ Vaccines (2020)

Comparison of shortened mosaic HIV-1 vaccine schedules: a randomised, double-blind, placebo-controlled phase 1 trial (IPCAVD010/HPX1002) and a preclinical study in rhesus monkeys (...

por Stephenson, Kathryn E., Wegmann, Frank, Tomaka, Frank, Walsh, Stephen R., Tan, C. Sabrina, Lavreys, Ludo, Ansel, Jessica L., Kanjilal, Diane G., Jaegle, Kate, Nkolola, Joseph P., Peter, Lauren, Fogel, Rachel, Bradshaw, Connor, Tyler, Anna, Makoni, Tatenda, Howe, Lisa, Quijada, Darla, Chandrashekar, Abishek, Bondzie, Esther A., Borducchi, Erica N., Yanosick, Katherine E., Hendriks, Jenny, Nijs, Steven, Truyers, Carla, Tolboom, Jeroen, Zahn, Roland C., Seaman, Michael S., Alter, Galit, Stieh, Daniel J., Pau, Maria Grazia, Schuitemaker, Hanneke, Barouch, Dan H.
Publicado en Lancet HIV (2020)

Low-Dose Ad26.COV2.S Protection Against SARS-CoV-2 Challenge in Rhesus Macaques

por He, Xuan, Chandrashekar, Abishek, Zahn, Roland, Wegmann, Frank, Yu, Jingyou, Mercado, Noe B., McMahan, Katherine, Martinot, Amanda J., Piedra-Mora, Cesar, Beecy, Sidney, Ducat, Sarah, Chamanza, Ronnie, Huber, Sietske Rosendahl, van der Fits, Leslie, Borducchi, Erica N., Lifton, Michelle, Liu, Jinyan, Nampanya, Felix, Patel, Shivani, Peter, Lauren, Tostanoski, Lisa H., Pessaint, Laurent, Van Ry, Alex, Finneyfrock, Brad, Velasco, Jason, Teow, Elyse, Brown, Renita, Cook, Anthony, Andersen, Hanne, Lewis, Mark G., Schuitemaker, Hanneke, Barouch, Dan H.
Publicado en bioRxiv (2021)

Low-dose Ad26.COV2.S protection against SARS-CoV-2 challenge in rhesus macaques

por He, Xuan, Chandrashekar, Abishek, Zahn, Roland, Wegmann, Frank, Yu, Jingyou, Mercado, Noe B., McMahan, Katherine, Martinot, Amanda J., Piedra-Mora, Cesar, Beecy, Sidney, Ducat, Sarah, Chamanza, Ronnie, Huber, Sietske Rosendahl, van Heerden, Marjolein, van der Fits, Leslie, Borducchi, Erica N., Lifton, Michelle, Liu, Jinyan, Nampanya, Felix, Patel, Shivani, Peter, Lauren, Tostanoski, Lisa H., Pessaint, Laurent, Van Ry, Alex, Finneyfrock, Brad, Velasco, Jason, Teow, Elyse, Brown, Renita, Cook, Anthony, Andersen, Hanne, Lewis, Mark G., Schuitemaker, Hanneke, Barouch, Dan H.
Publicado en Cell (2021)

Ad26.COV2.S protects Syrian hamsters against G614 spike variant SARS-CoV-2 and does not enhance respiratory disease

por van der Lubbe, Joan E. M., Rosendahl Huber, Sietske K., Vijayan, Aneesh, Dekking, Liesbeth, van Huizen, Ella, Vreugdenhil, Jessica, Choi, Ying, Baert, Miranda R. M., Feddes-de Boer, Karin, Izquierdo Gil, Ana, van Heerden, Marjolein, Dalebout, Tim J., Myeni, Sebenzile K., Kikkert, Marjolein, Snijder, Eric J., de Waal, Leon, Stittelaar, Koert J., Tolboom, Jeroen T. B. M., Serroyen, Jan, Muchene, Leacky, van der Fits, Leslie, Rutten, Lucy, Langedijk, Johannes P. M., Barouch, Dan H., Schuitemaker, Hanneke, Zahn, Roland C., Wegmann, Frank
Publicado en NPJ Vaccines (2021)

Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters

por Tostanoski, Lisa H., Wegmann, Frank, Martinot, Amanda J., Loos, Carolin, McMahan, Katherine, Mercado, Noe B., Yu, Jingyou, Chan, Chi N., Bondoc, Stephen, Starke, Carly E., Nekorchuk, Michael, Busman-Sahay, Kathleen, Piedra-Mora, Cesar, Wrijil, Linda M., Ducat, Sarah, Custers, Jerome, Atyeo, Caroline, Fischinger, Stephanie, Burke, John S., Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Bondzie, Esther A., Dagotto, Gabriel, Gebre, Makda S., Jacob-Dolan, Catherine, Lin, Zijin, Mahrokhian, Shant H., Nampanya, Felix, Nityanandam, Ramya, Pessaint, Laurent, Porto, Maciel, Ali, Vaneesha, Benetiene, Dalia, Tevi, Komlan, Andersen, Hanne, Lewis, Mark G., Schmidt, Aaron G., Lauffenburger, Douglas A., Alter, Galit, Estes, Jacob D., Schuitemaker, Hanneke, Zahn, Roland, Barouch, Dan H.
Publicado en Nat Med (2020)

Immunogenicity and efficacy of one and two doses of Ad26.COV2.S COVID vaccine in adult and aged NHP

por Solforosi, Laura, Kuipers, Harmjan, Jongeneelen, Mandy, Rosendahl Huber, Sietske K., van der Lubbe, Joan E.M., Dekking, Liesbeth, Czapska-Casey, Dominika N., Izquierdo Gil, Ana, Baert, Miranda R.M., Drijver, Joke, Vaneman, Joost, van Huizen, Ella, Choi, Ying, Vreugdenhil, Jessica, Kroos, Sanne, de Wilde, Adriaan H., Kourkouta, Eleni, Custers, Jerome, van der Vlugt, Remko, Veldman, Daniel, Huizingh, Jeroen, Kaszas, Krisztian, Dalebout, Tim J., Myeni, Sebenzile K., Kikkert, Marjolein, Snijder, Eric J., Barouch, Dan H., Böszörményi, Kinga P., Stammes, Marieke A., Kondova, Ivanela, Verschoor, Ernst J., Verstrepen, Babs E., Koopman, Gerrit, Mooij, Petra, Bogers, Willy M.J.M., van Heerden, Marjolein, Muchene, Leacky, Tolboom, Jeroen T.B.M., Roozendaal, Ramon, Brandenburg, Boerries, Schuitemaker, Hanneke, Wegmann, Frank, Zahn, Roland C.
Publicado en J Exp Med (2021)

DNA vaccine protection against SARS-CoV-2 in rhesus macaques

por Yu, Jingyou, Tostanoski, Lisa H., Peter, Lauren, Mercado, Noe B., McMahan, Katherine, Mahrokhian, Shant H., Nkolola, Joseph P., Liu, Jinyan, Li, Zhenfeng, Chandrashekar, Abishek, Martinez, David R., Loos, Carolin, Atyeo, Caroline, Fischinger, Stephanie, Burke, John S., Slein, Matthew D., Chen, Yuezhou, Zuiani, Adam, Lelis, Felipe J. N., Travers, Meghan, Habibi, Shaghayegh, Pessaint, Laurent, Van Ry, Alex, Blade, Kelvin, Brown, Renita, Cook, Anthony, Finneyfrock, Brad, Dodson, Alan, Teow, Elyse, Velasco, Jason, Zahn, Roland, Wegmann, Frank, Bondzie, Esther A., Dagotto, Gabriel, Gebre, Makda S., He, Xuan, Jacob-Dolan, Catherine, Kirilova, Marinela, Kordana, Nicole, Lin, Zijin, Maxfield, Lori F., Nampanya, Felix, Nityanandam, Ramya, Ventura, John D., Wan, Huahua, Cai, Yongfei, Chen, Bing, Schmidt, Aaron G., Wesemann, Duane R., Baric, Ralph S., Alter, Galit, Andersen, Hanne, Lewis, Mark G., Barouch, Dan H.
Publicado en Science (2020)