Low-dose Ad26.COV2.S protection against SARS-CoV-2 challenge in rhesus macaques

We previously reported that a single immunization with an adenovirus serotype 26 (Ad26)-vector-based vaccine expressing an optimized SARS-CoV-2 spike (Ad26.COV2.S) protected rhesus macaques against SARS-CoV-2 challenge. To evaluate reduced doses of Ad26.COV2.S, 30 rhesus macaques were immunized once...

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Publicado en:Cell
Main Authors: He, Xuan, Chandrashekar, Abishek, Zahn, Roland, Wegmann, Frank, Yu, Jingyou, Mercado, Noe B., McMahan, Katherine, Martinot, Amanda J., Piedra-Mora, Cesar, Beecy, Sidney, Ducat, Sarah, Chamanza, Ronnie, Huber, Sietske Rosendahl, van Heerden, Marjolein, van der Fits, Leslie, Borducchi, Erica N., Lifton, Michelle, Liu, Jinyan, Nampanya, Felix, Patel, Shivani, Peter, Lauren, Tostanoski, Lisa H., Pessaint, Laurent, Van Ry, Alex, Finneyfrock, Brad, Velasco, Jason, Teow, Elyse, Brown, Renita, Cook, Anthony, Andersen, Hanne, Lewis, Mark G., Schuitemaker, Hanneke, Barouch, Dan H.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Inc. 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8166510/
https://ncbi.nlm.nih.gov/pubmed/34133941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.05.040
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