A Fusion Intermediate gp41 Immunogen Elicits Neutralizing Antibodies to HIV-1

The membrane-proximal external region (MPER) of the human immunodeficiency virus, type 1 (HIV-1) envelope glycoprotein subunit gp41 is targeted by potent broadly neutralizing antibodies 2F5, 4E10, and 10E8. These antibodies recognize linear epitopes and have been suggested to target the fusion inter...

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Main Authors: Lai, Rachel P. J., Hock, Miriam, Radzimanowski, Jens, Tonks, Paul, Hulsik, David Lutje, Effantin, Gregory, Seilly, David J., Dreja, Hanna, Kliche, Alexander, Wagner, Ralf, Barnett, Susan W., Tumba, Nancy, Morris, Lynn, LaBranche, Celia C., Montefiori, David C., Seaman, Michael S., Heeney, Jonathan L., Weissenhorn, Winfried
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Microbiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208001/
https://ncbi.nlm.nih.gov/pubmed/25160627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.569566
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