An Endogenous Serine/Threonine Protein Phosphatase Inhibitor, G-Substrate, Reduces Vulnerability in Models of Parkinson's Disease

מאת Chung, Chee Yeun, Koprich, James B., Endo, Shogo, Isacson, Ole
יצא לאור 2007

Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease

מאת Koprich, James B, Reske-Nielsen, Casper, Mithal, Prabhakar, Isacson, Ole
יצא לאור 2008

Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV α-Synucleinopathy

מאת Chung, Chee Yeun, Koprich, James B., Siddiqi, Hasan, Isacson, Ole
יצא לאור 2009

Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression

מאת Chung, Chee Yeun, Koprich, James B., Hallett, Penelope J., Isacson, Ole
יצא לאור 2009

The Toll-Like Receptor-3 Agonist Polyinosinic:Polycytidylic Acid Triggers Nigrostriatal Dopaminergic Degeneration

מאת Deleidi, Michela, Hallett, Penelope J., Koprich, James B., Chung, Chee-Yeun, Isacson, Ole
יצא לאור 2010

Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson’s Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Ex...

מאת Koprich, James B., Johnston, Tom H., Reyes, Gabriela, Omana, Vanessa, Brotchie, Jonathan M.
הוצא לאור ב PLoS One (2016)

Exosome markers of LRRK2 kinase inhibition

מאת Wang, Shijie, Kelly, Kaela, Brotchie, Jonathan M., Koprich, James B., West, Andrew B.
הוצא לאור ב NPJ Parkinsons Dis (2020)

Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite...

מאת Koprich, James B, Johnston, Tom H, Reyes, M Gabriela, Sun, Xuan, Brotchie, Jonathan M
יצא לאור 2010

Update on Molecular Imaging in Parkinson’s Disease

מאת Liu, Zhen-Yang, Liu, Feng-Tao, Zuo, Chuan-Tao, Koprich, James B., Wang, Jian
הוצא לאור ב Neurosci Bull (2017)

GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson’s Disease

מאת Schneider, Jay S., Aras, Radha, Williams, Courtney K., Koprich, James B., Brotchie, Jonathan M., Singh, Vikrant
הוצא לאור ב Sci Rep (2019)

Progressive Neurodegeneration or Endogenous Compensation in an Animal Model of Parkinson's Disease Produced by Decreasing Doses of Alpha-Synuclein

מאת Koprich, James B., Johnston, Tom H., Huot, Philippe, Reyes, M. Gabriela, Espinosa, Maria, Brotchie, Jonathan M.
יצא לאור 2011

Subthalamic nucleus deep brain stimulation is neuroprotective in the A53T α‐synuclein Parkinson's disease rat model

מאת Musacchio, Thomas, Rebenstorff, Maike, Fluri, Felix, Brotchie, Jonathan M., Volkmann, Jens, Koprich, James B., Ip, Chi Wang
הוצא לאור ב Ann Neurol (2017)

The Promise and Challenges of Developing miRNA-Based Therapeutics for Parkinson’s Disease

מאת Titze-de-Almeida, Simoneide S., Soto-Sánchez, Cristina, Fernandez, Eduardo, Koprich, James B., Brotchie, Jonathan M., Titze-de-Almeida, Ricardo
הוצא לאור ב Cells (2020)

Reproducibility of a parkinsonism-related metabolic brain network in non-human primates: A descriptive pilot study with FDG PET

מאת Ma, Yilong, Johnston, Tom H., Peng, Shichun, Zuo, Chuantao, Koprich, James B., Fox, Susan H., Guan, Yihui, Eidelberg, David, Brotchie, Jonathan M.
הוצא לאור ב Mov Disord (2015)

Non-steric-zipper models for pathogenic α-synuclein conformers

מאת Schuman, Brock, Won, Amy, Brand-Arzamendi, Koroboshka, Koprich, James B., Wen, Xiao-Yan, Howson, Patrick A., Brotchie, Jonathan M., Yip, Christopher M.
הוצא לאור ב APL Bioeng (2018)

Nigrostriatal Dysfunction in Familial Alzheimer's Disease-Linked APPswe/PS1ΔE9 Transgenic Mice

מאת Perez, Sylvia E., Lazarov, Orly, Koprich, James B., Chen, Er-Yun, Rodriguez-Menendez, Virginia, Lipton, Jack W., Sisodia, Sangram S., Mufson, Elliott J.
הוצא לאור ב J Neurosci (2005)

AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new m...

מאת Ip, Chi Wang, Klaus, Laura-Christin, Karikari, Akua A., Visanji, Naomi P., Brotchie, Jonathan M., Lang, Anthony E., Volkmann, Jens, Koprich, James B.
הוצא לאור ב Acta Neuropathol Commun (2017)

Characterization of 3,4-Methylenedioxymethamphetamine (MDMA) Enantiomers In Vitro and in the MPTP-Lesioned Primate: R-MDMA Reduces Severity of Dyskinesia, Whereas S-MDMA Extends Du...

מאת Huot, Philippe, Johnston, Tom H., Lewis, Katie D., Koprich, James B., Reyes, M. Gabriela, Fox, Susan H., Piggott, Matthew J., Brotchie, Jonathan M.
הוצא לאור ב J Neurosci (2011)

α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms

מאת Chiu, Wei-Hua, Kovacheva, Lora, Musgrove, Ruth E., Arien-Zakay, Hadar, Koprich, James B., Brotchie, Jonathan M., Yaka, Rami, Ben-Zvi, Danny, Hanani, Menachem, Roeper, Jochen, Goldberg, Joshua A.
הוצא לאור ב Sci Adv (2021)

Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury

מאת Ip, Chi Wang, Isaias, Ioannis U., Kusche-Tekin, Burak B., Klein, Dennis, Groh, Janos, O’Leary, Aet, Knorr, Susanne, Higuchi, Takahiro, Koprich, James B., Brotchie, Jonathan M., Toyka, Klaus V., Reif, Andreas, Volkmann, Jens
הוצא לאור ב Acta Neuropathol Commun (2016)