Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease

BACKGROUND: The pathological hallmarks of Parkinson's disease (PD) include the presence of alpha-synuclein (α-syn) rich Lewy bodies and neurites and the loss of dopaminergic (DA) neurons of the substantia nigra (SN). Animal models of PD based on viral vector-mediated over-expression of α-syn ha...

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Main Authors: Koprich, James B, Johnston, Tom H, Reyes, M Gabriela, Sun, Xuan, Brotchie, Jonathan M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2984491/
https://ncbi.nlm.nih.gov/pubmed/21029459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-43
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