rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration

BACKGROUND: Alpha-synuclein is a key protein implicated in the pathogenesis of Parkinson's disease (PD). It is the main component of the Lewy bodies, a cardinal neuropathological feature in the disease. In addition, whole locus multiplications and point mutations in the gene coding for alpha-sy...

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Vydáno v:Mol Neurodegener
Hlavní autoři: Oliveras-Salvá, Marusela, Van der Perren, Anke, Casadei, Nicolas, Stroobants, Stijn, Nuber, Silke, D’Hooge, Rudi, Van den Haute, Chris, Baekelandt, Veerle
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222878/
https://ncbi.nlm.nih.gov/pubmed/24267638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-8-44
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