Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration

BACKGROUND: Alpha-synuclein is a key protein in the pathogenesis of Parkinson’s disease. Mutations in the parkin gene are the most common cause of early-onset autosomal recessive Parkinson’s disease, probably through a loss-of-function mechanism. However, the molecular mechanism by which loss of par...

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Publicado en:Mol Neurodegener
Main Authors: Van Rompuy, Anne-Sophie, Oliveras-Salvá, Marusela, Van der Perren, Anke, Corti, Olga, Van den Haute, Chris, Baekelandt, Veerle
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477319/
https://ncbi.nlm.nih.gov/pubmed/26099628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0017-8
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