Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease

BACKGROUND: The etiology of Parkinson's disease (PD) remains elusive despite identification of several genetic mutations. It is more likely that multiple factors converge to give rise to PD than any single cause. Here we report that inflammation can trigger degeneration of dopamine (DA) neurons...

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Autori principali: Koprich, James B, Reske-Nielsen, Casper, Mithal, Prabhakar, Isacson, Ole
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2008
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292163/
https://ncbi.nlm.nih.gov/pubmed/18304357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-5-8
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