Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease

BACKGROUND: The etiology of Parkinson's disease (PD) remains elusive despite identification of several genetic mutations. It is more likely that multiple factors converge to give rise to PD than any single cause. Here we report that inflammation can trigger degeneration of dopamine (DA) neurons...

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Hlavní autoři: Koprich, James B, Reske-Nielsen, Casper, Mithal, Prabhakar, Isacson, Ole
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2008
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292163/
https://ncbi.nlm.nih.gov/pubmed/18304357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-5-8
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