The Path for Metal Complexes to a DNA Target

Por Komor, Alexis C., Barton, Jacqueline K.
Publicado em 2013

An Unusual Ligand Coordination Gives Rise to a New Family of Rhodium Metalloinsertors with Improved Selectivity and Potency

Por Komor, Alexis C., Barton, Jacqueline K.
Publicado em 2014

Selective Cytotoxicity of Rhodium Metalloinsertors in Mismatch Repair-Deficient Cells()

Por Ernst, Russell J., Komor, Alexis C., Barton, Jacqueline K.
Publicado em 2011

Biological effects of simple changes in functionality on rhodium metalloinsertors

Por Weidmann, Alyson G., Komor, Alexis C., Barton, Jacqueline K.
Publicado em 2013

Targeted Chemotherapy with Metal Complexes

Por Weidmann, Alyson G., Komor, Alexis C., Barton, Jacqueline K.
Publicado no Comments Mod Chem A Comments Inorg Chem (2014)

CRISPR-based technologies for the manipulation of eukaryotic genomes

Por Komor, Alexis C., Badran, Ahmed H., Liu, David R.
Publicado no Cell (2016)

Editing the Genome Without Double-Stranded DNA Breaks

Por Komor, Alexis C., Badran, Ahmed H., Liu, David R.
Publicado no ACS Chem Biol (2017)

Cell-Selective Biological Activity of Rhodium Metalloinsertors Correlates with Subcellular Localization

Por Komor, Alexis C., Schneider, Curtis J., Weidmann, Alyson G., Barton, Jacqueline K.
Publicado em 2012

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

Por Komor, Alexis C., Kim, Yongjoo B., Packer, Michael S., Zuris, John A., Liu, David R.
Publicado no Nature (2016)

Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions

Por Kim, Y. Bill, Komor, Alexis C., Levy, Jonathan M., Packer, Michael S., Zhao, Kevin T., Liu, David R.
Publicado no Nat Biotechnol (2017)

An Inducible, Isogenic Cancer Cell Line System for Targeting the State of Mismatch Repair Deficiency

Por Bailis, Julie M., Gordon, Marcia L., Gurgel, Jesse L., Komor, Alexis C., Barton, Jacqueline K., Kirsch, Ilan R.
Publicado em 2013

Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery

Por Rees, Holly A., Komor, Alexis C., Yeh, Wei-Hsi, Caetano-Lopes, Joana, Warman, Matthew, Edge, Albert S. B., Liu, David R.
Publicado no Nat Commun (2017)

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

Por Gaudelli, Nicole M., Komor, Alexis C., Rees, Holly A., Packer, Michael S., Badran, Ahmed H., Bryson, David I., Liu, David R.
Publicado no Nature (2017)

Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

Por Komor, Alexis C., Zhao, Kevin T., Packer, Michael S., Gaudelli, Nicole M., Waterbury, Amanda L., Koblan, Luke W., Kim, Y. Bill, Badran, Ahmed H., Liu, David R.
Publicado no Sci Adv (2017)