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CRISPR-based technologies for the manipulation of eukaryotic genomes

The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances in the life sciences that have grown from the ability to edit genomes within living cells. In this review we summarize CRISPR-based technologies that enable mammalian genome editing and their various applications...

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Publicat a:Cell
Autors principals: Komor, Alexis C., Badran, Ahmed H., Liu, David R.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5235943/
https://ncbi.nlm.nih.gov/pubmed/27866654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.10.044
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