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Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
The spontaneous deamination of cytosine is a major source of C•G to T•A transitions, which account for half of known human pathogenic point mutations. The ability to efficiently convert target A•T base pairs to G•C therefore could advance the study and treatment of genetic diseases. While the deamin...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5726555/ https://ncbi.nlm.nih.gov/pubmed/29160308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24644 |
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