Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

The spontaneous deamination of cytosine is a major source of C•G to T•A transitions, which account for half of known human pathogenic point mutations. The ability to efficiently convert target A•T base pairs to G•C therefore could advance the study and treatment of genetic diseases. While the deamin...

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Bibliografiska uppgifter
I publikationen:Nature
Huvudupphovsmän: Gaudelli, Nicole M., Komor, Alexis C., Rees, Holly A., Packer, Michael S., Badran, Ahmed H., Bryson, David I., Liu, David R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726555/
https://ncbi.nlm.nih.gov/pubmed/29160308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24644
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