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Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
Current genome-editing technologies introduce double-stranded (ds) DNA breaks at a target locus as the first step to gene correction.(1,2) Although most genetic diseases arise from point mutations, current approaches to point mutation correction are inefficient and typically induce an abundance of r...
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| Publicado no: | Nature |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4873371/ https://ncbi.nlm.nih.gov/pubmed/27096365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17946 |
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