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Search-and-replace genome editing without double-strand breaks or donor DNA
Most genetic variants that contribute to disease(1) are challenging to correct efficiently and without excess byproducts(2–5). Here we describe prime editing, a versatile and precise genome editing method that directly writes new genetic information into a specified DNA site using a catalytically im...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6907074/ https://ncbi.nlm.nih.gov/pubmed/31634902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1711-4 |
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