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AAV-Mediated Gene Editing via Double-Strand Break Repair

Traditionally, the ability to edit the mammalian genome was inhibited by the inherent low efficiency of homologous recombination (HR; approximately <1 in a million events) and the inability to deliver DNA efficiently to dividing and non-dividing cells/tissue. Despite these limitations, creative s...

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Vydáno v:Methods Mol Biol
Hlavní autoři: Hirsch, Matthew L., Samulski, R. Jude
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4971580/
https://ncbi.nlm.nih.gov/pubmed/24557911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-62703-761-7_19
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