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An Unusual Ligand Coordination Gives Rise to a New Family of Rhodium Metalloinsertors with Improved Selectivity and Potency
[Image: see text] Rhodium metalloinsertors are octahedral complexes that bind DNA mismatches with high affinity and specificity and exhibit unique cell-selective cytotoxicity, targeting mismatch repair (MMR)-deficient cells over MMR-proficient cells. Here we describe a new generation of metalloinser...
Gorde:
| Egile Nagusiak: | , |
|---|---|
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Chemical
Society
2014
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| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4195389/ https://ncbi.nlm.nih.gov/pubmed/25254630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5072064 |
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