CRISPR-Cas guides the future of genetic engineering

por Knott, Gavin J., Doudna, Jennifer A.
Publicado en Science (2018)

The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold

por Knott, Gavin J., Bond, Charles S., Fox, Archa H.
Publicado en Nucleic Acids Res (2016)

Controlling and enhancing CRISPR systems

por Shivram, Haridha, Cress, Brady F., Knott, Gavin J., Doudna, Jennifer A.
Publicado en Nat Chem Biol (2020)

Caenorhabditis elegans NONO‐1: Insights into DBHS protein structure, architecture, and function

por Knott, Gavin J., Lee, Mihwa, Passon, Daniel M., Fox, Archa H., Bond, Charles S.
Publicado en Protein Sci (2015)

RNA targeting by functionally orthogonal Type VI-A CRISPR-Cas enzymes

por East-Seletsky, Alexandra, O’Connell, Mitchell R., Burstein, David, Knott, Gavin J., Doudna, Jennifer A.
Publicado en Mol Cell (2017)

RNA-binding and HEPN-nuclease activation are decoupled in CRISPR-Cas13a

por Tambe, Akshay, East-Seletsky, Alexandra, Knott, Gavin J., Doudna, Jennifer A., O’Connell, Mitchell R.
Publicado en Cell Rep (2018)

A crystallographic study of human NONO (p54(nrb)): overcoming pathological problems with purification, data collection and noncrystallographic symmetry

por Knott, Gavin J., Panjikar, Santosh, Thorn, Andrea, Fox, Archa H., Conte, Maria R., Lee, Mihwa, Bond, Charles S.
Publicado en Acta Crystallogr D Struct Biol (2016)

Structures of the CRISPR genome integration complex

por Wright, Addison V., Liu, Jun-Jie, Knott, Gavin J., Doxzen, Kevin W., Nogales, Eva, Doudna, Jennifer A.
Publicado en Science (2017)

Evidence for Ancient Origins of Bowman-Birk Inhibitors from Selaginella moellendorffii

por James, Amy M., Jayasena, Achala S., Zhang, Jingjing, Berkowitz, Oliver, Secco, David, Knott, Gavin J., Whelan, James, Bond, Charles S., Mylne, Joshua S.
Publicado en Plant Cell (2017)

Machine learning predicts new anti-CRISPR proteins

por Eitzinger, Simon, Asif, Amina, Watters, Kyle E, Iavarone, Anthony T, Knott, Gavin J, Doudna, Jennifer A, Minhas, Fayyaz ul Amir Afsar
Publicado en Nucleic Acids Res (2020)

Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme

por Knott, Gavin J., East-Seletsky, Alexandra, Cofsky, Joshua C., Holton, James M., Charles, Emeric, O’Connell, Mitchell R., Doudna, Jennifer A.
Publicado en Nat Struct Mol Biol (2017)

Broad-spectrum enzymatic inhibition of CRISPR-Cas12a

por Knott, Gavin J., Thornton, Brittney W., Lobba, Marco J., Liu, Jun-Jie, Al-Shayeb, Basem, Watters, Kyle E., Doudna, Jennifer A.
Publicado en Nat Struct Mol Biol (2019)

CRISPR-CasΦ from huge phages is a hypercompact genome editor

por Pausch, Patrick, Al-Shayeb, Basem, Bisom-Rapp, Ezra, Tsuchida, Connor A., Li, Zheng, Cress, Brady F., Knott, Gavin J., Jacobsen, Steven E., Banfield, Jillian F., Doudna, Jennifer A.
Publicado en Science (2020)

Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage

por Amen, Alexandra M., Fellmann, Christof, Soczek, Katarzyna M., Ren, Shawn M., Lew, Rachel J., Knott, Gavin J., Park, Jesslyn E., McKinney, Andrew M., Mancini, Andrew, Doudna, Jennifer A., Costello, Joseph F.
Publicado en Proc Natl Acad Sci U S A (2021)

Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a

por Knott, Gavin J, Cress, Brady F, Liu, Jun-Jie, Thornton, Brittney W, Lew, Rachel J, Al-Shayeb, Basem, Rosenberg, Daniel J, Hammel, Michal, Adler, Benjamin A, Lobba, Marco J, Xu, Michael, Arkin, Adam P, Fellmann, Christof, Doudna, Jennifer A
Publicado en eLife (2019)

Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles

por Hennig, Sven, Kong, Geraldine, Mannen, Taro, Sadowska, Agata, Kobelke, Simon, Blythe, Amanda, Knott, Gavin J., Iyer, K. Swaminathan, Ho, Diwei, Newcombe, Estella A., Hosoki, Kana, Goshima, Naoki, Kawaguchi, Tetsuya, Hatters, Danny, Trinkle-Mulcahy, Laura, Hirose, Tetsuro, Bond, Charles S., Fox, Archa H.
Publicado en J Cell Biol (2015)

A Broad-Spectrum Inhibitor of CRISPR-Cas9

por Harrington, Lucas B., Doxzen, Kevin W., Ma, Enbo, Liu, Jun-Jie, Knott, Gavin J., Edraki, Alireza, Garcia, Bianca, Amrani, Nadia, Chen, Janice S., Cofsky, Joshua C., Kranzusch, Philip J., Sontheimer, Erik J., Davidson, Alan R., Maxwell, Karen L., Doudna, Jennifer A.
Publicado en Cell (2017)

CRISPR-CasX is an RNA-dominated enzyme active for human genome editing

por Liu, Jun-Jie, Orlova, Natalia, Oakes, Benjamin L., Ma, Enbo, Spinner, Hannah B., Baney, Katherine L.M., Chuck, Jonathan, Tan, Dan, Knott, Gavin J., Harrington, Lucas B., Al-Shayeb, Basem, Wagner, Alexander, Brötzmann, Julian, Staahl, Brett T., Talyor, Kian L., Desmarais, John, Nogales, Eva, Doudna, Jennifer A.
Publicado en Nature (2019)

Rapid, point-of-care molecular diagnostics with Cas13

por Agrawal, Shreeya, Fanton, Alison, Chandrasekaran, Sita S., Charrez, Bérénice, Escajeda, Arturo M., Son, Sungmin, Mcintosh, Roger, Bhuiya, Abdul, de León Derby, María Díaz, Switz, Neil A., Armstrong, Maxim, Harris, Andrew R., Prywes, Noam, Lukarska, Maria, Biering, Scott B., Smock, Dylan C. J., Mok, Amanda, Knott, Gavin J., Dang, Qi, Van Dis, Erik, Dugan, Eli, Kim, Shin, Liu, Tina Y., Harris, Eva, Stanley, Sarah A., Lareau, Liana F., Tan, Ming X., Fletcher, Daniel A., Doudna, Jennifer A., Savage, David F., Hsu, Patrick D.
Publicado en medRxiv (2021)

Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy

por Fozouni, Parinaz, Son, Sungmin, Díaz de León Derby, María, Knott, Gavin J., Gray, Carley N., D’Ambrosio, Michael V., Zhao, Chunyu, Switz, Neil A., Kumar, G. Renuka, Stephens, Stephanie I., Boehm, Daniela, Tsou, Chia-Lin, Shu, Jeffrey, Bhuiya, Abdul, Armstrong, Maxim, Harris, Andrew R., Chen, Pei-Yi, Osterloh, Jeannette M., Meyer-Franke, Anke, Joehnk, Bastian, Walcott, Keith, Sil, Anita, Langelier, Charles, Pollard, Katherine S., Crawford, Emily D., Puschnik, Andreas S., Phelps, Maira, Kistler, Amy, DeRisi, Joseph L., Doudna, Jennifer A., Fletcher, Daniel A., Ott, Melanie
Publicado en Cell (2021)