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RNA targeting by functionally orthogonal Type VI-A CRISPR-Cas enzymes
CRISPR adaptive immunity pathways protect prokaryotic cells against foreign nucleic acids using CRISPR RNA (crRNA)-guided nucleases. In Type VI-A CRISPR-Cas systems, the signature protein Cas13a (formerly C2c2) contains two separate ribonuclease activities that catalyze crRNA maturation and ssRNA de...
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| Publicado en: | Mol Cell |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5999320/ https://ncbi.nlm.nih.gov/pubmed/28475872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.04.008 |
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