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RNA targeting by functionally orthogonal Type VI-A CRISPR-Cas enzymes

CRISPR adaptive immunity pathways protect prokaryotic cells against foreign nucleic acids using CRISPR RNA (crRNA)-guided nucleases. In Type VI-A CRISPR-Cas systems, the signature protein Cas13a (formerly C2c2) contains two separate ribonuclease activities that catalyze crRNA maturation and ssRNA de...

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Bibliografski detalji
Izdano u:Mol Cell
Glavni autori: East-Seletsky, Alexandra, O’Connell, Mitchell R., Burstein, David, Knott, Gavin J., Doudna, Jennifer A.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5999320/
https://ncbi.nlm.nih.gov/pubmed/28475872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.04.008
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