Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme

CRISPR adaptive immune systems protect bacteria from infections by deploying CRISPR RNA (crRNA)-guided enzymes to recognize and cut foreign nucleic acids. Type VI-A CRISPR-Cas systems include the Cas13a enzyme, an RNA-activated ribonuclease (RNase) capable of crRNA processing and single-stranded RNA...

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Bibliographic Details
Published in:Nat Struct Mol Biol
Main Authors: Knott, Gavin J., East-Seletsky, Alexandra, Cofsky, Joshua C., Holton, James M., Charles, Emeric, O’Connell, Mitchell R., Doudna, Jennifer A.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961731/
https://ncbi.nlm.nih.gov/pubmed/28892041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3466
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