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RNA-binding and HEPN-nuclease activation are decoupled in CRISPR-Cas13a
CRISPR-Cas13a enzymes are RNA-guided, RNA-activated ribonucleases. Their properties have been exploited as powerful tools for RNA detection, RNA imaging and RNA regulation. However, the relationship between target RNA binding and HEPN (higher-eukaryotes-and-prokaryotes nucleotide-binding)- domain nu...
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| 出版年: | Cell Rep |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6085867/ https://ncbi.nlm.nih.gov/pubmed/30044970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.105 |
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