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Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d
Cas13d, the type VI-D CRISPR-Cas effector, is an RNA-guided ribonuclease that has been repurposed to edit RNA in a programmable manner. Here we report the detailed structural and functional analysis of the uncultured Ruminococcus sp. Cas13d (UrCas13d)-crRNA complex. Two hydrated Mg(2+) ions aid in s...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6559982/ https://ncbi.nlm.nih.gov/pubmed/31186424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10507-3 |
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