Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d

Cas13d, the type VI-D CRISPR-Cas effector, is an RNA-guided ribonuclease that has been repurposed to edit RNA in a programmable manner. Here we report the detailed structural and functional analysis of the uncultured Ruminococcus sp. Cas13d (UrCas13d)-crRNA complex. Two hydrated Mg(2+) ions aid in s...

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Udgivet i:Nat Commun
Main Authors: Zhang, Bo, Ye, Yangmiao, Ye, Weiwei, Perčulija, Vanja, Jiang, Han, Chen, Yiyang, Li, Yu, Chen, Jing, Lin, Jinying, Wang, Siqi, Chen, Qi, Han, Yu-San, Ouyang, Songying
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559982/
https://ncbi.nlm.nih.gov/pubmed/31186424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10507-3
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