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Two Distinct RNase Activities of CRISPR-C2c2 Enable Guide RNA Processing and RNA Detection
Bacterial adaptive immune systems employ CRISPRs (clustered regularly interspaced short palindromic repeats) and CRISPR-associated (Cas) proteins for RNA-guided nucleic acid cleavage(1,2). Although generally targeted to DNA substrates(3–5), the Type III and Type VI CRISPR systems direct interference...
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| Gepubliceerd in: | Nature |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5576363/ https://ncbi.nlm.nih.gov/pubmed/27669025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature19802 |
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