Broad-spectrum enzymatic inhibition of CRISPR-Cas12a

Cas12a (Cpf1) is a bacterial RNA-guided nuclease used widely for genome editing and diagnostic applications. In bacteria, Cas12a enzymes can be inhibited by bacteriophage-derived proteins, anti-CRISPRs (Acrs), to thwart clustered regularly interspaced short palindromic repeat (CRISPR) adaptive immun...

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Udgivet i:Nat Struct Mol Biol
Main Authors: Knott, Gavin J., Thornton, Brittney W., Lobba, Marco J., Liu, Jun-Jie, Al-Shayeb, Basem, Watters, Kyle E., Doudna, Jennifer A.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6449189/
https://ncbi.nlm.nih.gov/pubmed/30936531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0208-z
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