MDM2 negatively regulates the human telomerase RNA gene promoter

por Zhao, Jiangqin, Bilsland, Alan, Jackson, Katrina, Keith, W Nicol
Publicado 2005

Properties of a Telomerase-Specific Cre/Lox Switch for Transcriptionally Targeted Cancer Gene Therapy

por Bilsland, Alan E., Fletcher-Monaghan, Aileen, Keith, W. Nicol
Publicado 2005

The hTERT and hTERC Telomerase Gene Promoters Are Activated by the Second Exon of the Adenoviral Protein, E1A, Identifying the Transcriptional Corepressor CtBP as a Potential Repre...

por Glasspool, Rosalind M, Burns, Sharon, Hoare, Stacey F, Svensson, Catharina, Keith, W Nicol
Publicado 2005

Mapping of the Gene for the Human Telomerase Reverse Transcriptase, hTERT, to Chromosome 5p15.33 by Fluorescence in Situ Hybridization

por Bryce, Lisa A, Morrison, Norma, Hoare, Stacey F, Muir, Sharon, Keith, W Nicol
Publicado 2000

Activation of Telomerase RNA Gene Promoter Activity by NF-Y, Sp1, and the Retinoblastoma Protein and Repression by Sp3

por Zhao, Jiang-Qin, Glasspool, Rosalind M, Hoare, Stacey F, Bilsland, Alan, Szatmari, Istvan, Keith, W Nicol
Publicado 2000

Mathematical Model of a Telomerase Transcriptional Regulatory Network Developed by Cell-Based Screening: Analysis of Inhibitor Effects and Telomerase Expression Mechanisms

por Bilsland, Alan E., Stevenson, Katrina, Liu, Yu, Hoare, Stacey, Cairney, Claire J., Roffey, Jon, Keith, W. Nicol
Publicado 2014

Extensive telomere erosion is consistent with localised clonal expansions in Barrett’s metaplasia

por Letsolo, Boitelo T., Jones, Rhiannon E., Rowson, Jan, Grimstead, Julia W., Keith, W. Nicol, Jenkins, Gareth J. S., Baird, Duncan M.
Publicado en PLoS One (2017)

A gene expression signature classifying telomerase and ALT immortalisation reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT

por Lafferty-Whyte, Kyle, Cairney, Claire J., Will, Malcolm B., Serakinci, Nedime, Daidone, Maria-Grazia, Zaffaroni, Nadia, Bilsland, Alan, Keith, W. Nicol
Publicado 2009

Zoning of Mucosal Phenotype, Dysplasia, and Telomerase Activity Measured by Telomerase Repeat Assay Protocol in Barrett's Esophagus

por Going, James J, Fletcher-Monaghan, Aileen J, Neilson, Lisa, Wisman, Bea A, van der Zee, Ate, Stuart, Robert C, Keith, W Nicol
Publicado 2004

A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation

por Bilsland, Alan E., Liu, Yu, Turnbull, Andrew, Sumpton, David, Stevenson, Katrina, Cairney, Claire J., Boyd, Susan M., Roffey, Jon, Jenkinson, David, Keith, W. Nicol
Publicado en Neoplasia (2019)

Immortalization of T-Cells Is Accompanied by Gradual Changes in CpG Methylation Resulting in a Profile Resembling a Subset of T-Cell Leukemias()()()

por Degerman, Sofie, Landfors, Mattias, Siwicki, Jan Konrad, Revie, John, Borssén, Magnus, Evelönn, Emma, Forestier, Erik, Chrzanowska, Krystyna H., Rydén, Patrik, Keith, W. Nicol, Roos, Göran
Publicado 2014

A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria

por Keith, W Nicol, Vulliamy, Tom, Zhao, Jiangqin, Ar, Cem, Erzik, Can, Bilsland, Alan, Ulku, Birsen, Marrone, Anna, Mason, Philip J, Bessler, Monica, Serakinci, Nedime, Dokal, Inderjeet
Publicado 2004

Dynamic Telomerase Gene Suppression via Network Effects of GSK3 Inhibition

por Bilsland, Alan E., Hoare, Stacey, Stevenson, Katrina, Plumb, Jane, Gomez-Roman, Natividad, Cairney, Claire, Burns, Sharon, Lafferty-Whyte, Kyle, Roffey, Jon, Hammonds, Tim, Keith, W. Nicol
Publicado 2009

Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition

por Sadaie, Mahito, Dillon, Christian, Narita, Masashi, Young, Andrew R. J., Cairney, Claire J., Godwin, Lauren S., Torrance, Christopher J., Bennett, Dorothy C., Keith, W. Nicol, Narita, Masashi
Publicado en Mol Biol Cell (2015)

Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel an...

por Lafferty-Whyte, Kyle, Bilsland, Alan, Cairney, Claire J, Hanley, Lorna, Jamieson, Nigel B, Zaffaroni, Nadia, Oien, Karin A, Burns, Sharon, Roffey, Jon, Boyd, Susan M, Keith, W Nicol
Publicado 2010

Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks()()

por Bilsland, Alan E., Pugliese, Angelo, Liu, Yu, Revie, John, Burns, Sharon, McCormick, Carol, Cairney, Claire J., Bower, Justin, Drysdale, Martin, Narita, Masashi, Sadaie, Mahito, Keith, W. Nicol
Publicado en Neoplasia (2015)

Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression

por Soo, Julia K, MacKenzie Ross, Alastair D, Kallenberg, David M, Milagre, Carla, Heung Chong, W, Chow, Jade, Hill, Lucy, Hoare, Stacey, Collinson, Rebecca S, Hossain, Mehnaz, Keith, W Nicol, Marais, Richard, Bennett, Dorothy C
Publicado 2011

A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A

por Zhang, Xin, Neganova, Irina, Przyborski, Stefan, Yang, Chunbo, Cooke, Michael, Atkinson, Stuart P., Anyfantis, George, Fenyk, Stefan, Keith, W. Nicol, Hoare, Stacey F., Hughes, Owen, Strachan, Tom, Stojkovic, Miodrag, Hinds, Philip W., Armstrong, Lyle, Lako, Majlinda
Publicado 2009

A ‘synthetic-sickness’ screen for senescence re-engagement targets in mutant cancer backgrounds

por Cairney, Claire J., Godwin, Lauren S., Bilsland, Alan E., Burns, Sharon, Stevenson, Katrina H., McGarry, Lynn, Revie, John, Moore, Jon D., Wiggins, Ceri M., Collinson, Rebecca S., Mudd, Clare, Tsonou, Elpida, Sadaie, Mahito, Bennett, Dorothy C., Narita, Masashi, Torrance, Christopher J., Keith, W. Nicol
Publicado en PLoS Genet (2017)

Therapeutic targeting of replicative immortality

por Yaswen, Paul, MacKenzie, Karen L., Keith, W. Nicol, Hentosh, Patricia, Rodier, Francis, Zhu, Jiyue, Firestone, Gary L., Matheu, Ander, Carnero, Amancio, Bilsland, Alan, Sundin, Tabetha, Honoki, Kanya, Fujii, Hiromasa, Georgakilas, Alexandros G., Amedei, Amedeo, Amin, Amr, Helferich, Bill, Boosani, Chandra S., Guha, Gunjan, Ciriolo, Maria Rosa, Chen, Sophie, Mohammed, Sulma I., Azmi, Asfar S., Bhakta, Dipita, Halicka, Dorota, Niccolai, Elena, Aquilano, Katia, Ashraf, S. Salman, Nowsheen, Somaira, Yang, Xujuan
Publicado en Semin Cancer Biol (2015)