A ‘synthetic-sickness’ screen for senescence re-engagement targets in mutant cancer backgrounds

Senescence is a universal barrier to immortalisation and tumorigenesis. As such, interest in the use of senescence-induction in a therapeutic context has been gaining momentum in the past few years; however, senescence and immortalisation remain underserved areas for drug discovery owing to a lack o...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Cairney, Claire J., Godwin, Lauren S., Bilsland, Alan E., Burns, Sharon, Stevenson, Katrina H., McGarry, Lynn, Revie, John, Moore, Jon D., Wiggins, Ceri M., Collinson, Rebecca S., Mudd, Clare, Tsonou, Elpida, Sadaie, Mahito, Bennett, Dorothy C., Narita, Masashi, Torrance, Christopher J., Keith, W. Nicol
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570495/
https://ncbi.nlm.nih.gov/pubmed/28806777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006942
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